MT-45 (IC-6) is an opioid analgesic drug invented in the 1970s by Dainippon Pharmaceutical Co. It is chemically a 1-substituted-4-(1,2-diphenylethyl)piperazine derivative, which is structurally unrelated to most other opioid drugs. Racemic MT-45 has around 80% the potency of morphine, with almost all opioid activity residing in the (S) enantiomer (the opposite stereochemistry from the related drug lefetamine). It has been used as a lead compound from which a large family of potent opioid drugs have been developed, including full agonists, partial agonists, and antagonists at the three main opioid receptor subtypes.
Recreational use of MT-45 has been associated with hearing loss and unconsciousness.
MT-45 became a class A drug in the UK on 11 March 2015
See also
- AD-1211
- AH-7921
- Diphenidine
- IC-26
- Lefetamine
References
