1-(2-Pyrimidinyl)piperazine (1-PP, 1-PmP) is a chemical compound and piperazine derivative. It is known to act as an α2-adrenergic receptor antagonist, and as a 5-HT1A receptor partial agonist to a much lesser extent. It does not appear to have any significant affinity for the D2 or α1-adrenergic receptors.
A number of pyrimidinylpiperazine derivatives are drugs, including:
- Buspirone - anxiolytic
- Dasatinib - anticancer agent
- Eptapirone - anxiolytic
- Gepirone - anxiolytic
- Ipsapirone - anxiolytic
- Piribedil - antiparkinsonian agent
- Revospirone - anxiolytic
- Tandospirone - anxiolytic
- Tirilazad - neuroprotective agent
- Umespirone - anxiolytic
- Zalospirone - anxiolytic
The anxiolytics are also classified as azapirones due to the azaspirodecanedione moiety in their structures. 1-PP is a common metabolite of most or all of the listed agents. Alnespirone, binospirone, and enilospirone, despite being azapirones, are not piperazines and therefore do not metabolize to 1-PP, and while perospirone and tiospirone are piperazines, they are instead benzothiazole-substituted piperazines and do not metabolize to 1-PP either.
See also
- Pyridinylpiperazine
- Phenylpiperazine
- Diphenylmethylpiperazine
- Benzylpiperazine