N-Methyltryptamine (NMT), or methyltryptamine, is a member of the tryptamine chemical class. It is an alkaloid, probably derived from L-tryptophan, that has been found in the bark, shoots and leaves of several plant species, including Virola, Acacia, Mimosa and Desmanthus often together with the related compounds N,N-dimethyltryptamine (DMT) and 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT). It is also synthesized in the human body as a metabolic endproduct of the amino acid L-tryptophan. It was found to be a natural trace component in human urine.
Orally administered NMT appears to produce no psychoactive effects, likely as a result of extensive first-pass metabolism. However, it may become active upon combination with a MAOA inhibitor (MAOI). By vaporization NMT shows activity at 50â€"100 mg, with a duration of 45â€"70 minutes; duration of visual effects 15â€"30 seconds. Effects are primarily non-visual.
NMT has been shown to act as an agonist of the TAAR1, similarly to its relatives tryptamine and N,N-dimethyltryptamine.
§See also
- N-Ethyltryptamine (NET)
- N,N,-Dimethyltryptamine (DMT)
- Acacia confusa (a natural source of NMT, with other tryptamines, 1.63%. Buchanan et al. 2007)
- Acacia obtusifolia (NMT up to 2/3 alkaloid content)
- Acacia simplicifolia (synon. A. simplex) (1.44% NMT in bark, 0.29% twigs, Pouet et al. 1976)
- Desmanthus Illinoensis (NMT major component seasonally)
§References
§External links
- NMT Entry in TIHKAL
- NMT Entry in TiHKAL • info